Hairy cell leukemia variant (HCLV) is an example of an unclassifiable splenic Bcell leukemialymphoma. It is included in the World Health Organization (WHO) classification as a provisional entity, no longer biologically related to classic HCL.
Hairy cell leukemia is an uncommon hematological malignancy characterized by an accumulation of abnormal B lymphocytes. Hairy cell leukemiavariant, or HCLV, is usually described as a prolymphocytic variant of hairy cell leukemia.
Feb 11, 2015 Hairy cell leukemia variant is a chronic lymphoproliferative disorder whose characteristics resemble the classic form and SMZL, making differential diagnosis essential for therapeutic followup, as hairy cell leukemia variant has a decreased response to drugs prescribed for the classic form.
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